No, it doesn't make any difference,
*Unless* you're buying a Certified Pre-Owned.
In order to qualify for CPO, OEMs require dealers to recondition their used cars to a very specific standard.
And every OEM holds its franchisees to a different standard.
Regardless, there may still be no difference between buying a CPO
buying the same car from a reputable used dealership.
I know many used car dealerships that recondition all of their cars to CPO standards.
If not higher.